Evaluation of the Antifungal Activity of Five Medicinal Plants on the in vitro Growth of a Multi-resistant Strain of Candida Albicans

Authors

  • Konan Gbê Kouakou N'dri Ange Biology and Health Laboratory, UFR Biosciences, Université Félix Houphouët-Boigny, Abidjan, Côte d'Ivoire
  • Ouattara Sitapha Biology and Health Laboratory, UFR Biosciences, Université Félix Houphouët-Boigny, Abidjan, Côte d'Ivoire
  • Kanga Yao Ethnobotanical-Ethnopharmacological Laboratory, UFR Sciences Biologiques, Université Peleforo Gon Coulibaly, Korhogo, Côte d'Ivoire
  • Monney Yapo Urbain Biology and Health Laboratory, UFR Biosciences, Université Félix Houphouët-Boigny, Abidjan, Côte d’Ivoire
  • Kra Adou Koffi Mathieu Biology and Health Laboratory, UFR Biosciences, Université Félix Houphouët-Boigny, Abidjan, Côte d’Ivoire

Keywords:

Phytochemical screening, Antifungal activity, Medicinal plants

Abstract

This study was conducted to determine the antifungal potential of plants traditionally used in the treatment of infections. Five (5) plants were collected. The anti-candida albicans activity was evaluated by the double dilution method in tilted tubes with the aqueous and hydroethanolic extracts of the different plants. The results showed that the 70% ethanolic extracts were more active than the aqueous extracts for all plants. The 70% ethanolic extract of T. ivorensis (FMC = 1.56 mg/ml) was the most active on the tested strain. It was followed by T. superba (MFC = 3.125 mg/ml) D. benthamianus (MFC = 50 mg/mL), G. arborea (MFC= 50 mg/mL) and J. secunda (MFC ˃ 50 mg/mL). The phytochemical screening revealed the presence of seven major groups of compounds, among which saponins and catechins are the most abundant in the aqueous extracts. Polyphenols, Flavonoids, Polyterpenes and Sterols as well as Tannins are equally present in the alcoholic and aqueous extracts of the different plants at variable levels. These compounds could justify its activity and its traditional use. 

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Published

2022-09-24

How to Cite

N’dri Ange, K. G. K., Sitapha, O., Yao, K., Urbain, M. Y., & Mathieu, K. A. K. (2022). Evaluation of the Antifungal Activity of Five Medicinal Plants on the in vitro Growth of a Multi-resistant Strain of Candida Albicans. ESI Preprints, 9, 579. Retrieved from https://esipreprints.org/index.php/esipreprints/article/view/72

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Section

Preprints