Food-drug Interactions in Patients with Cardiovascular Diseases
Keywords:: Interaction, food, drugs, anticoagulants
Cardiovascular diseases are one of the most common diseases in the world. Anticoagulants and other drugs are prescribed as treatment for these diseases however, polypharmacy may increase the risk of drug-drug or fooddrug interatrions and decrease patient compliance. Food-drug interatrions may put the patient at risk for serious adverse effects and reduce safety and efficacy of treatment. Food‐drug interaction is a common problem that has occurred as a result of the concomitant use of multiple drugs with food. Food-drug interaction is the term used to describe how a food affects a medication in the body. Food can alter the effectiveness of medication, make unwanted side effects better or worse, or even bring on brand-new negative effects. Drugs may alter how the body processes food. Consumption of foods which contain vitamin K make anticoagulant therapy less effective. On the other hand, patients should be careful when consuming foods like: garlic, ginseng, ginger and ginkgo in order to avoid the undesirable effect of hemorrhage. Healthcare professionals should advice patients taking anticoagulants to be careful with the food they consume and clinicians should manage the time and dose variability of the medicine so a successful therapy can be achieved.
Ansell J, McDonough M, Zhao Y, Harmatz JS, Greenblatt DJ. The
absence of an interaction between warfarin and cranberry juice: a
randomized, double-blind trial. J Clin Pharmacol 2009.
Jul;49(7):824-830 10.1177/0091270009337510 [PubMed] [CrossRef]
Boucher, J. n.d. Common Food-Drug Interactions
Bushra, R., Aslam, N., Khan, A. Y. (2011). Food-drug interactions,
Oman Med J. ;26(2):77-83.doi: 10.5001/omj.2011.21.
Choi, J. H. and Ko, Ch. M.(2017). Food and Drug Interactions,
PMID: 28261555, doi: 10.15280/jlm.2017.7.1.1
Fleisher D, Li C, Zhou Y, Pao L-H, Karim A. Drug, Meal and
Formulation Interactions Influencing Drug Absorption After Oral
Administration. Clin Pharmacokinet. 1999;36:233–54. doi:
2165/00003088-199936030-00004. [PubMed] [CrossRef]
Genser D. Food and drug interaction: consequences for the
nutrition/health status. Ann Nutr Metab 2008;52(Suppl 1):29-32
1159/000115345 [PubMed] [CrossRef]
Hornsby LB, Hester EK, Donaldson AR. Potential interaction
between warfarin and high dietary protein intake. Pharmacotherapy
Apr;28(4):536-539 10.1592/phco.28.4.536 [PubMed]
Kirby, B. J., Unadkat, J. D. (2007). Grapefruit juice, a glass full of
drug interactions? , Clin Pharmacol Ther.;81(5):631-3.doi:
Lourenco R. Enteral feeding: drug/nutrient interaction. Clin Nutr.
;20:187–93. doi: 10.1054/clnu.2000.0155. [PubMed] [CrossRef]
McCabe BJ, Frankel EH, Wolfe JJ. (2003). Monitoring nutritional
status in drug regimens. In: Hand book of food-drug Interactions,
McCabe BJ, Frankel EH., Wolfe JJ (Eds.). CRC Press, Boca Raton.
pp 73-108 [Google Scholar]
Melander, A. (1978). Influence of food on the bioavailability of
drugs, PMID: 81118, DOI: 10.2165/00003088-197803050-00001.
Rodriguez-Fragoso L, Martinez-Arismendi JL, Orozco-Bustos D,
Reyes-Esparza J, Torres E, Burchiel SW. Potential risks resulting
from fruit/vegetable-drug interactions: effects on drug-metabolizing
enzymes and drug transporters. J Food Sci. 2011;76:R112–24. doi:
1111/j.1750-3841.2011.02155.x. [PubMed] [CrossRef]
Wittkowsky AK. Dietary supplements, herbs and oral anticoagulants:
the nature of the evidence. J Thromb Thrombolysis 2008.
Feb;25(1):72-77 10.1007/s11239-007-0110-0 [PubMed] [CrossRef]
Won CS, Oberlies NH, Paine MF. Mechanisms underlying fooddrug
interactions: inhibition of intestinal metabolism and transport.
Pharmacol Ther. 2012;136:186–201. doi:
1016/j.pharmthera.2012.08.001. [PMC free article] [PubMed]
Zhou S, Gao Y, Jiang W, Huang M, Xu A, Paxton JW. Interactions
of herbs with cytochrome P450. Drug Metab Rev. 2003;35:35–98.
doi: 10.1081/DMR-120018248. [PubMed] [CrossRef]
Grześk, G., Rogowicz, D.,Wołowiec, Ł., Ratajczak, A., Gilewski,W.,
Chudzińska, M., Sinkiewicz, A., and Banach, J. D. (2021). The
Clinical Significance of Drug–Food Interactions of Direct Oral
Anticoagulants, PMID: 34445237, doi: 10.3390/ijms22168531
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