Haematic Potentials of Rhynchospore Corymbosa and Olax Subscorpioïdea Extract in Phenylhydrazine – induced Anaemic Rats

M’béfèhê Soro; Joël Akakpo- Akue; Jacques Auguste Alfred Bognan Ackah; Jean-François  Sibri; Yayé Guillaume  Yapi; Tatiana Kangah Mireille Kple; Sihi Ephrem Léangeovers Getheme Sanko

Authors

M’béfèhê Soro Agro-valuation Laboratory and Agroforestry, UFR Agroforestrie, Jean Lorougnon Guédé University (UJLoG), Ivory Coast
Joël Akakpo- Akue Laboratory of Pharmacodynamic and Biochemistry, UFR Biosciences, Université Félix Houphouët-Boigny (UFHB), Côte d’Ivoire
Jacques Auguste Alfred Bognan Ackah Agro-valuation Laboratory and Agroforestry, UFR Agroforestrie, Jean Lorougnon Guédé University (UJLoG), Ivory Coast
Jean-François Sibri Agro-valuation Laboratory and Agroforestry, UFR Agroforestrie, Jean Lorougnon Guédé University (UJLoG), Ivory Coast
Yayé Guillaume Yapi Agro-valuation Laboratory and Agroforestry, UFR Agroforestrie, Jean Lorougnon Guédé University (UJLoG), Ivory Coast
Tatiana Kangah Mireille Kple Laboratory of Pharmacodynamic and Biochemistry, UFR Biosciences, Université Félix Houphouët-Boigny (UFHB), Côte d’Ivoire
Sihi Ephrem Léangeovers Getheme Sanko Laboratory of biology, Agropastoral Management Institute, Péléforo Gbon Coulibaly university, Côte d’Ivoire

Keywords:

Antianemic activity, R. corymbose,, O. subscorpioïdea, sickle cell, decoction

Abstract

The decoction of the whole plant of Rhynchospora corymbosa and Olax subscorpioïdea leaves are used by the Local traditional healers in the department of Korhogo (Northern Côte d’Ivoire) to treat patients with sickle cell disease. This study was designed to assess, the antianemic potential of these plants extract. Anemia was induced with phenylhydrazine hydrochloride in rats. Animals were divided in normal (N), control (C), test (T), and reference (R) groups. T group included ill-induced Animals treated with R. corymbosa and O. subscorpioidea extracts, and R group ill-induced animals treated with vitamin B9 for anemic animals. Dosing was made as 1- day single dose repeated dose. In anemic animals, the production rate of RBC was significantly (p < 0.001) higher in T group as compared to C group. R. corymbosa whole plant and O. subscorpioidea leaves extracts have a haematic potential. The anti-anaemic effect may partly explain their use in patients with sickle cell disease who are affected by a deficiency of erythrocytes and its components.

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Haematic Potentials of Rhynchospore Corymbosa and Olax Subscorpioïdea Extract in Phenylhydrazine – induced Anaemic Rats

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